AICAR: Research, Dosing Reports, and Safety in 2026
A research-first profile for AICAR (IICAR, Icar), aggregating mechanism notes, transcript dosing mentions, vendor recommendations, and PubMed-indexed literature without presenting medical guidance.
AICAR is a research compound profiled here from named-expert transcripts and peer-reviewed literature, without medical guidance. As of July 2026, The Peptide Wiki aggregates 8 PubMed-cited papers, 5 attributed expert mentions, and 3 transcript dosing protocols for AICAR, each linked to its source.
- Also indexed as IICAR, Icar.
- 3 aggregated dosing-protocol mentions from source transcripts.
- 8 PubMed-indexed citations listed in the research table below.
- 0 vendor recommendations captured from named experts.
What is AICAR?
AICAR, also indexed as IICAR and Icar, is a research compound profiled here from named-expert transcripts and PubMed-indexed literature. No disease-treatment claims are made on this page; every entry is aggregated and cited to its source.
Experts on background and overview · 3 cited mentions
"And then if you throw in the Icar Combining Icar with data is a little bit risky. I tried to look into the drug interactions but it's a little Well, it both has to do with ATP regeneration and how that's signaled."
"if you take Icar, if you take whatever is promoting actual beta fatty acid beta oxidation in the mitochondria, then you need the shuttling of triglycerides"
"We'd rather leverage things like EPO, myo-inositol triphosphate, cardarine, AICAR, all the metabolic modulators."
AICAR Dosing Protocols
This section aggregates 3 transcript-derived AICAR dosing mentions from named experts. Each is preserved for research context and is not medical advice.
| Speaker | Source | Timestamp | Protocol | Evidence |
|---|---|---|---|---|
| Vigorous Steve | Debunking Growth Hormone Myths, Insulin Resistance, Fat Loss,... | 01:51:01 | Steve reported that 50 mg produces noticeable fat-loss and performance effects (versus a clinical dose of 500 mg), diluting heavily with 2 to 3 cc bacteriostatic water per 50 mg or 0.5% acetic acid. | anecdotal |
| Vigorous Steve | Injectable SLU, AI Dosing Protocol, Glutathione & NAD+, GH & Insulin... | 00:28:37 | Steve reported a protocol of 25 mg bilaterally into trained muscle for localized effects, with systemic effective doses reported at 250 to 500 mg. | anecdotal |
| VigorousClips | This Is What MMA Fighters Take And Try To Hide | Stamina, Endurance,... | 00:07:02 | VigorousClips reported 25 to 100 mg SubQ 30 to 60 minutes before sparring or a match, with IV administration before sparring noted as an alternative when SubQ post-injection pain is intolerable, using a discreet IV site, stacked with Cardarine and L-Carnitine, and cycled 21 days on / 21 days off. | anecdotal |
AICAR Vendor Tracking
No tracked vendor recommendations for AICAR yet. See our vendor directory.
Side Effects and Safety
Anecdotal reports and study-level observations vary by route, dose, and individual. This page does not provide medical advice. Consult a qualified clinician before any research use.
What Experts Say
One expert in our source library discusses AICAR. Each entry is that expert’s most context-rich mention: click to watch it at the exact timestamp in the original video. Quotes are also emitted as Schema.org Quotation JSON-LD for AI assistants.
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“And then if you throw in the Icar Combining Icar with data is a little bit risky. I tried to look into the drug interactions but it's a little Well, it both has to do with ATP regeneration and how...”
See 2 more expert mentions →
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“if you take Icar, if you take whatever is promoting actual beta fatty acid beta oxidation in the mitochondria, then you need the shuttling of triglycerides”
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“We'd rather leverage things like EPO, myo-inositol triphosphate, cardarine, AICAR, all the metabolic modulators.”
User Reviews
User reviews aggregator coming Q3 2026 (Reddit + YouTube comments + Discord research notes). Until then, see the expert quote section above and PubMed citations below.
Research and Studies
8 PubMed-indexed papers reference AICAR. All 8 are listed below with PMID, authors, journal, year, and DOI.
Legal Status
AICAR is presented here as a research compound. FDA approval status, scheduling, WADA status, and state-specific telehealth rules may apply. Always verify current regulatory status. Last verified: 2026-07-05.
Frequently Asked Questions
Is AICAR FDA-approved?
AICAR is presented on this page as a research compound. FDA approval status, scheduling, and state-specific rules may apply and change. Verify current regulatory status before any decision.
What dosing is reported for AICAR?
This page aggregates 3 dosing-protocol mentions from named-expert transcripts, each linked to a verbatim source timestamp. See the Dosing Protocols table above. Mentions are anecdotal, not medical advice.
How much research has been published on AICAR?
8 PubMed-indexed papers reference AICAR in our current research feed. See the Research and Studies section above for citations.