The Peptide Wiki
Mapping Knowledge.
Advancing Discovery.
📩 Subscribe
Last updated · 19 new expert mentions this week
Peptide Profile

MK-677 (Ibutamoren): Research, Dosing, and Where to Buy in 2026

A research-first profile for MK-677 (Ibutamoren) (MK677), aggregating mechanism notes, transcript dosing mentions, vendor recommendations, and PubMed-indexed literature without presenting medical guidance.

Quick Answer

MK-677 (Ibutamoren) is a research compound profiled here from named-expert transcripts and peer-reviewed literature, without medical guidance. As of July 2026, The Peptide Wiki aggregates 8 PubMed-cited papers, 7 attributed expert mentions, 6 transcript dosing protocols, and 1 referenced vendor for MK-677 (Ibutamoren), each linked to its source.

Key Facts
Sarm
  • Also indexed as MK677.
  • 6 aggregated dosing-protocol mentions from source transcripts.
  • 8 PubMed-indexed citations listed in the research table below.
  • 1 vendor recommendation captured from named experts.
Sourced to expert
Check vendor COA
Verify dose w/ clinician

What is MK-677 (Ibutamoren)?

Research compound aggregated from creator and literature mentions. No direct disease-treatment claims are made on this page.

Experts on background and overview · 4 cited mentions

"Do you use growth hormone a couple times per day or MK-677 or another growth hormone secretagogue, right? I have the combinations in those videos."
Vigorous Steve · Nebido For Traveling, Skin-Friendly PEDs, GH Carpal... @ 32:06
"run MK-677 pre-bed 30 micrograms per day for a couple weeks, and then switch to growth hormone"
Vigorous Steve · Oral Vs Injectable SLU-PP-332, Ideal GH To Test Ratio,... @ 1:41:02
"Tan MK677 and Carterine for body composition... you can't improve your body composition in a slight surplus when you're ravenously hungry on MK677."
Vigorous Steve · Trenbolone’s Minimum Dose, Generic GH Gone, SS-31... @ 24:34
Show 1 more cited mention on background and overview →
"Some sort of other appetite suppression in the form of MK-677 or a GHRP-6, right? The actual digestion is the issue, not the hunger."
Vigorous Steve · Pool Party Protocols, 16-Week Tren Cycle, No GH Bloat,... @ 17:08

MK-677 (Ibutamoren) Dosing Protocols

The entries below are transcript-derived dosing mentions. They are preserved for research context and are not medical advice.

SpeakerSourceTimestampProtocolEvidence
Vigorous Steve Injectable SLU, AI Dosing Protocol, Glutathione & NAD+, GH & Insulin... 01:08:46 Steve reported that 10 mg with good diet may match 20 mg with poor diet for IGF-1 response. anecdotal
Vigorous Steve Oral Vs Injectable SLU-PP-332, Ideal GH To Test Ratio, High... 01:41:02 Vigorous Steve reported using 30 mcg pre-bed daily (quote retained verbatim from source). anecdotal
VS Are Secretagogues Actually Worth It? Or Should You Just Go With HGH? 00:03:38 VS reported: 20-30 mg orally before bed every day anecdotal
The Peptide Podcast The Magic of MK-677 00:01:15 Reported protocol: Oral tablet by mouth before bedtime or at dinner with a large meal; reported use cycles typically 8 to 12 weeks. anecdotal
TPC (Alex Kikel) GROWTH HORMONE PEPTIDES (SEMINAR & PROTOCOLS) 00:25:34 Long-term moderate dosing discussed at 5, 10, 15, 20, or 25 mg; speaker does not favor going above 25 mg unless necessary. anecdotal
Boost Your Biology (Lucas Aoun) MK-777: New Growth Hormone Booster BEATS MK-677!? 00:03:11 Speaker reported personal use of 20 mg daily, taken 30 minutes before bed. anecdotal

Where to Buy MK-677 (Ibutamoren) in 2026

Side Effects and Safety

Anecdotal reports and study-level observations vary by route, dose, and individual. This page does not provide medical advice. Consult a qualified clinician before any research use.

What Experts Say

1 expert across our source library discuss MK-677 (Ibutamoren). Each entry is that expert’s most context-rich mention: click to watch it at the exact timestamp in the original video. Quotes are also emitted as Schema.org Quotation JSON-LD for AI assistants.

  1. Vigorous Steve · Nebido For Traveling, Skin-Friendly PEDs, GH Carpal...Watch @ 32:06 ↗

    “Do you use growth hormone a couple times per day or MK-677 or another growth hormone secretagogue, right? I have the combinations in those videos.”

See 3 more expert mentions →
  1. Vigorous Steve · Oral Vs Injectable SLU-PP-332, Ideal GH To Test Ratio,...Watch @ 1:41:02 ↗

    “run MK-677 pre-bed 30 micrograms per day for a couple weeks, and then switch to growth hormone”

  2. Vigorous Steve · Trenbolone’s Minimum Dose, Generic GH Gone, SS-31...Watch @ 24:34 ↗

    “Tan MK677 and Carterine for body composition... you can't improve your body composition in a slight surplus when you're ravenously hungry on MK677.”

  3. Vigorous Steve · Pool Party Protocols, 16-Week Tren Cycle, No GH Bloat,...Watch @ 17:08 ↗

    “Some sort of other appetite suppression in the form of MK-677 or a GHRP-6, right? The actual digestion is the issue, not the hunger.”

User Reviews

User reviews aggregator coming Q3 2026 (Reddit + YouTube comments + Discord research notes). Until then, see the expert quote section above and PubMed citations below.

Research Efficacy Snapshot

Published efficacy percentages cited in PubMed trials and named-expert reports about MK-677 (Ibutamoren). Each line links to the original source.

  • "Intramuscular androgen receptor (-44.6%), testosterone (+47.8%) and dihydrotestosterone (+34.4%), in addition to one-repetition maximum leg press and bench press (+39.2 and +32.0%, respectively), were different in the case subject compared with non-users." · Cardaci T et al, 2022 PubMed
  • "MK-677, with or without alendronate, increased insulin-like growth factor I levels from baseline (39% and 45%; P < 0.05 vs." · Murphy M et al, 2001 PubMed
  • "MK-677 increased osteocalcin and urinary NTx by 22% and 41%, on the average, respectively (P < 0.05 vs." · Murphy M et al, 2001 PubMed
  • "MK-677 and alendronate mitigated the reduction in bone formation compared with alendronate alone based on mean relative changes in serum osteocalcin (-40% vs." · Murphy M et al, 2001 PubMed
  • "-54%; P < 0.05, combination vs." · Murphy M et al, 2001 PubMed
  • "alendronate) and reduced the effect of alendronate on resorption (NTx) as well (-52% vs." · Murphy M et al, 2001 PubMed
  • "-61%; P < 0.05, combination vs." · Murphy M et al, 2001 PubMed
  • "MK-677 plus alendronate increased BMD at the femoral neck (4.2% vs." · Murphy M et al, 2001 PubMed
  • "2.5% for alendronate; P < 0.05)." · Murphy M et al, 2001 PubMed
  • "Treatment with 10 mg and 25 mg of MK-677 for 2 weeks increased mean urine NTXs 10% and 17%, respectively (p < 0.05 vs." · Murphy M et al, 1999 PubMed

MK-677 (Ibutamoren) Research Findings in Numbers

Quantitative results quoted verbatim from the indexed peer-reviewed studies and attributed clinical protocols below.

  • 30 mcg per day pre-bed for comparison vs GHRP-6 Steve
  • VS reported: 20-30 mg orally before bed every day VS
  • Steve reported that 10 mg with good diet may match 20 mg with poor diet for IGF-1 response. Steve
  • speaker does not favor going above 25 mg unless necessary. Speaker 1
  • reported use cycles typically 8 to 12 weeks. host
  • Patients who received MK-677 alone or placebo through month 12 received MK-677 (25 mg) plus alendronate (10 mg) from months 12-18. PMID 11238495
  • All patients received 500 mg/day calcium. PMID 11238495
  • Dose response data were initially obtained in healthy elderly subjects who received oral doses of 10 mg or 25 mg of MK-677 or placebo for 2 weeks (n = 10-12/group). PMID 10404019
  • Treatment with 10 mg and 25 mg of MK-677 for 2 weeks increased mean urine NTXs 10% and 17%, respectively (p &lt PMID 10404019
  • Additionally, 50 healthy elderly subjects received either placebo (n = 20) for 4 weeks or 25 mg of MK-677 (n = 30) daily for 2 weeks followed by 50 mg daily for 2 weeks. PMID 10404019
  • During the last 7 days of each diet period, subjects received either oral MK-677 25 mg or placebo once daily. PMID 9467534
  • MK-677 group -2.67 +/- 0.40 g/day vs. PMID 9467534
  • placebo group -2.83 +/- 0.26 g/day). PMID 9467534
  • MK-677 improved nitrogen balance integrated over the 7 days of treatment PMID 9467534
  • Doses were 5 and 25 mg MK-677 and matching placebo. PMID 9349662

Research and Studies

8 PubMed-indexed papers reference MK-677 (Ibutamoren). Top 8 shown.

Frequently Asked Questions

Is MK-677 (Ibutamoren) FDA-approved?

MK-677 (Ibutamoren) is presented on this page as a research compound. FDA approval status, scheduling, and state-specific rules may apply and change. Verify current regulatory status before any decision.

What dosing is reported for MK-677 (Ibutamoren)?

This page aggregates 6 dosing-protocol mention(s) from named-expert transcripts, each linked to a verbatim source timestamp. See the Dosing Protocols table above. Mentions are anecdotal, not medical advice.

Where can I buy MK-677 (Ibutamoren)?

1 vendor recommendation(s) are tracked in our directory, sourced from named-expert mentions. See the Where to Buy section above. Always verify COA and current regulatory status.

How much research has been published on MK-677 (Ibutamoren)?

8 PubMed-indexed paper(s) reference MK-677 (Ibutamoren) in our current research feed. See the Research and Studies section above for citations.