PE-22-28: Research, Dosing, and Where to Buy in 2026
A research-first profile for PE-22-28 (PE22-28, Spadin analog, Spadin (28-mer)), aggregating mechanism notes, transcript dosing mentions, vendor recommendations, and PubMed-indexed literature without presenting medical guidance.
28-amino-acid peptide derived from sortilin / Spadin precursor. As of July 2026, The Peptide Wiki aggregates 8 PubMed-cited papers, 8 attributed expert mentions, and 5 transcript dosing protocols for PE-22-28, each linked to its source.
- Also indexed as PE22-28, Spadin analog, Spadin (28-mer).
- 28-amino-acid peptide derived from sortilin / Spadin precursor. Researched as a fast-acting antidepressant via TREK-1 potassium channel blockade.
- Mechanism notes include Selective TREK-1 (potassium two-pore channel) blocker. Increases serotonergic neurotransmission similar to SSRIs but acts much faster (days vs weeks).
- 5 aggregated dosing-protocol mentions from source transcripts.
- 8 PubMed-indexed citations listed in the research table below.
- 0 vendor recommendations captured from named experts.
- Evidence level in this entry is marked as research.
What is PE-22-28?
28-amino-acid peptide derived from sortilin / Spadin precursor. Researched as a fast-acting antidepressant via TREK-1 potassium channel blockade.
How does PE-22-28 work?
Selective TREK-1 (potassium two-pore channel) blocker. Increases serotonergic neurotransmission similar to SSRIs but acts much faster (days vs weeks).
Mechanism note
These mechanisms are presented as research observations and hypotheses from the indexed data, not as confirmation of clinical effect in humans.
Experts on mechanism · 1 cited mention
"It is going to wake up those uh the connections between your neurotransmitters and allow you to like, wow, see the beauty in things, right? And be happy and laugh and smile."
What is PE-22-28 researched for?
Mood-boosting / antidepressant. Tanner reports feeling 'closer to a million bucks' the day after dosing, especially when stacked with Melanotan 2.
Experts on uses and effects · 3 cited mentions
"Tanner reported on PE 22-28: he described it as a 'mood boosting peptide,' stating that after use he wakes up the next day feeling 'a lot closer to a million bucks,' particularly when combined with melanotan. (Individual user account; not medical advice.)"
"Will reported that PE-22-28 has been discussed as functioning similarly to an anti-depressant, with users reporting effects focused on mood changes."
"I think the main focus of PE228 is uh the main focus is going to be enhancing mood."
PE-22-28 Dosing Protocols
The entries below are transcript-derived dosing mentions. They are preserved for research context and are not medical advice.
| Speaker | Source | Timestamp | Protocol | Evidence |
|---|---|---|---|---|
| Will (JD Denham co-host) | Peptide of the Week: PE-22-28, pinealon & Cerebrolysin - Mood,... | 00:13:16 | Subcutaneous: top out at ~500 mcg. Start at 100 mcg and work up to 500 mcg. 10 mg bottle reconstituted with 2 mL bac water = 10 units gives 500 mcg; start at 5 units daily and work up to 10 units. | anecdotal |
| Tanner Tattered | Tanner Tattered: Peptides & Drugs for Long-term Bodybuilding Success | 01:25:12 | Subcutaneous, dosing experimental - Tanner stacks with Melanotan 2 for combined mood/sexual benefit | anecdotal |
| JD Denham | Peptide of the Week: PE-22-28, pinealon & Cerebrolysin - Mood,... | 00:14:10 | For depression, can go straight to 500 mcg daily for about a week to see effect. | anecdotal |
| Hunter | Saturday Morning Coffee Talk 6/6/26 | 00:38:37 | Hunter says injectable and nasal felt the same to him, but for depression he would try both and maybe nasal spray first because it is easier and may cross to CNS faster. | anecdotal |
| The Hunter Williams Podcast | Saturday Morning Coffee Talk 6/20/26 | 01:24:24 | Taylor felt using PE-22-28 more than three times per week may have affected sleep. | anecdotal |
Where to Buy PE-22-28 in 2026
No tracked vendor recommendations for PE-22-28 yet. See our vendor directory.
Side Effects and Safety
Anecdotal reports and study-level observations vary by route, dose, and individual. This page does not provide medical advice. Consult a qualified clinician before any research use.
What Experts Say
3 experts across our source library discuss PE-22-28. Each entry is that expert’s most context-rich mention: click to watch it at the exact timestamp in the original video. Quotes are also emitted as Schema.org Quotation JSON-LD for AI assistants.
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“Tanner reported on PE 22-28: he described it as a 'mood boosting peptide,' stating that after use he wakes up the next day feeling 'a lot closer to a million bucks,' particularly when combined...”
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“It is going to wake up those uh the connections between your neurotransmitters and allow you to like, wow, see the beauty in things, right? And be happy and laugh and smile.”
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“I think the main focus of PE228 is uh the main focus is going to be enhancing mood.”
See 2 more expert mentions →
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“Will reported that PE-22-28 has been discussed as functioning similarly to an anti-depressant, with users reporting effects focused on mood changes.”
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Will (JD Denham co-host) · Peptide of the Week: PE-22-28, pinealon & Cerebrolysin...Watch @ 35:27 ↗
“the add-on to the PE2228, I don't know if I said this, but like let's start start low. That stuff works fast and is very very effective.”
User Reviews
User reviews aggregator coming Q3 2026 (Reddit + YouTube comments + Discord research notes). Until then, see the expert quote section above and PubMed citations below.
Research Efficacy Snapshot
Published efficacy percentages cited in PubMed trials and named-expert reports about PE-22-28. Each line links to the original source.
- "Depression is a devastating mental disorder that affects 20% of the population worldwide." · Djillani A et al, 2017 PubMed
Research and Studies
8 PubMed-indexed papers reference PE-22-28. Top 8 shown.
Legal Status
PE-22-28 is presented here as a research compound. FDA approval status, scheduling, WADA status, and state-specific telehealth rules may apply. Always verify current regulatory status. Last verified: 2026-07-09.
Frequently Asked Questions
What is PE-22-28?
28-amino-acid peptide derived from sortilin / Spadin precursor. Researched as a fast-acting antidepressant via TREK-1 potassium channel blockade.
Is PE-22-28 FDA-approved?
PE-22-28 is presented on this page as a research compound. FDA approval status, scheduling, and state-specific rules may apply and change. Verify current regulatory status before any decision.
What dosing is reported for PE-22-28?
This page aggregates 5 dosing-protocol mention(s) from named-expert transcripts, each linked to a verbatim source timestamp. See the Dosing Protocols table above. Mentions are anecdotal, not medical advice.
How much research has been published on PE-22-28?
8 PubMed-indexed paper(s) reference PE-22-28 in our current research feed. See the Research and Studies section above for citations.