Raloxifene: Research, Dosing, and Where to Buy in 2026
A research-first profile for Raloxifene (ralo), aggregating mechanism notes, transcript dosing mentions, vendor recommendations, and PubMed-indexed literature without presenting medical guidance.
Raloxifene is a research compound profiled here from named-expert transcripts and peer-reviewed literature, without medical guidance. As of July 2026, The Peptide Wiki aggregates 8 PubMed-cited papers, 9 attributed expert mentions, and 3 transcript dosing protocols for Raloxifene, each linked to its source.
- Also indexed as ralo.
- 3 aggregated dosing-protocol mentions from source transcripts.
- 8 PubMed-indexed citations listed in the research table below.
- 0 vendor recommendations captured from named experts.
What is Raloxifene?
Research compound aggregated from creator and literature mentions. No direct disease-treatment claims are made on this page.
Experts on background and overview · 4 cited mentions
"It will reduce it 50% at 120 mg per day by reducing the inflammation and maybe the tissue. But then as soon as you stop, the tissue will fill up again and you still get that full blown gynecomastia."
"Once you have solid gyno tissue, no matter how many letrozole, raloxifene, whatever genie magic protocol you read on the internet, the only way that's getting out is through surgery."
"Gyno's not going away on 40 milligrams tamoxifen and 40 milligrams raloxifene for weeks. If you're already on 80 milligrams SERMs for four weeks and it's not going away, then it's surgery time. Continuing with the SERMs any longer than this is just risking blood clots and low IGF levels."
Show 1 more cited mention on background and overview →
"you tried the raloxifene and all that and it didn't shrink the gyno. So I would at this point I would just do the gyno surgery"
Raloxifene Dosing Protocols
The entries below are transcript-derived dosing mentions. They are preserved for research context and are not medical advice.
| Speaker | Source | Timestamp | Protocol | Evidence |
|---|---|---|---|---|
| Vigorous Steve | The ULTIMATE Hair Loss & Gyno Prevention Tier List (No Surgery Required) | 01:24:41 | 60-120 mg per day in early puffy stage of gyno to prevent growth; run 2-4 weeks until puffiness resolves then transition to AI to manage estradiol | anecdotal |
| Vigorous Steve | This Actually Changes Your Appearance, How You Can Lose Facial Fat... | 00:08:53 | Vigorous Steve reported using 60 to 120 mg daily over two divided dosages, noting approximately 50% reduction in gynecomastia. | anecdotal |
| Vigorous Steve | Ozempic Issues, Injectable Anadrol, Shrink Gyno, Hypo On Tren, PIP... | 00:31:46 | Gyno: Steve reported using 60 mg/day for 4 weeks, then 120 mg/day for 4 weeks | anecdotal |
Where to Buy Raloxifene in 2026
No tracked vendor recommendations for Raloxifene yet. See our vendor directory.
Side Effects and Safety
Anecdotal reports and study-level observations vary by route, dose, and individual. This page does not provide medical advice. Consult a qualified clinician before any research use.
What Experts Say
2 experts across our source library discuss Raloxifene. Each entry is that expert’s most context-rich mention: click to watch it at the exact timestamp in the original video. Quotes are also emitted as Schema.org Quotation JSON-LD for AI assistants.
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“It will reduce it 50% at 120 mg per day by reducing the inflammation and maybe the tissue. But then as soon as you stop, the tissue will fill up again and you still get that full blown gynecomastia.”
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“Once you have solid gyno tissue, no matter how many letrozole, raloxifene, whatever genie magic protocol you read on the internet, the only way that's getting out is through surgery.”
See 2 more expert mentions →
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“Gyno's not going away on 40 milligrams tamoxifen and 40 milligrams raloxifene for weeks. If you're already on 80 milligrams SERMs for four weeks and it's not going away, then it's surgery time....”
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“you tried the raloxifene and all that and it didn't shrink the gyno. So I would at this point I would just do the gyno surgery”
User Reviews
User reviews aggregator coming Q3 2026 (Reddit + YouTube comments + Discord research notes). Until then, see the expert quote section above and PubMed citations below.
Research Efficacy Snapshot
Published efficacy percentages cited in PubMed trials and named-expert reports about Raloxifene. Each line links to the original source.
- "Mean differences (MDs) and their 95% confidence intervals (CIs) were calculated using random effects models." · Peng T et al, 2025 PubMed
- "In investigations in animals and in rigorously conducted trials in humans, raloxifene treatment is associated with a 30%-40% reduction in risk of one or more spine fractures using the 60 mg dose." · Seeman E et al, 2001 PubMed
- "Raloxifene treatment also is associated with a 60%-70% reduction in risk for breast cancer and is associated with reduced total and LDL cholesterol, lower fibrinogen, and no rise in triglyceride." · Seeman E et al, 2001 PubMed
- "Raloxifene does not induce breast tenderness, endometrial hyperplasia, menstrual bleeding, or endometrial cancer, but may be associated with an increased risk of thromboembolic disease (1/1000 cases per year), leg cramps in 2%-4% of cases and hot flushes in 4%-6% of cases, usually in first 6 months." · Seeman E et al, 2001 PubMed
- "Approximately 60% of a dose is absorbed; however, absolute bioavailability is only 2%." · Snyder K et al, 2000 PubMed
- "Vigorous Steve reported that 60 to 120 mg of raloxifene daily over two divided dosages may reduce gynecomastia by approximately 50%." · Vigorous Steve on "This Actually Changes Your Appearance, How You Can Lose Faci" @ 8:53
- "It will reduce it 50% at 120 mg per day by reducing the inflammation and maybe the tissue." · Steve on "The ULTIMATE Hair Loss & Gyno Prevention Tier List (No Surge" @ 1:41:16
Research and Studies
8 PubMed-indexed papers reference Raloxifene. Top 8 shown.
Legal Status
Raloxifene is presented here as a research compound. FDA approval status, scheduling, WADA status, and state-specific telehealth rules may apply. Always verify current regulatory status. Last verified: 2026-07-09.
Frequently Asked Questions
Is Raloxifene FDA-approved?
Raloxifene is presented on this page as a research compound. FDA approval status, scheduling, and state-specific rules may apply and change. Verify current regulatory status before any decision.
What dosing is reported for Raloxifene?
This page aggregates 3 dosing-protocol mention(s) from named-expert transcripts, each linked to a verbatim source timestamp. See the Dosing Protocols table above. Mentions are anecdotal, not medical advice.
How much research has been published on Raloxifene?
8 PubMed-indexed paper(s) reference Raloxifene in our current research feed. See the Research and Studies section above for citations.