SS-31: Research, Dosing, and Where to Buy in 2026
A research-first profile for SS-31, aggregating mechanism notes, transcript dosing mentions, vendor recommendations, and PubMed-indexed literature without presenting medical guidance.
SS-31 is a research compound profiled here from named-expert transcripts and peer-reviewed literature, without medical guidance. As of July 2026, The Peptide Wiki aggregates 8 PubMed-cited papers, 40 attributed expert mentions, 15 transcript dosing protocols, and 4 referenced vendors for SS-31, each linked to its source.
- 15 aggregated dosing-protocol mentions from source transcripts.
- 8 PubMed-indexed citations listed in the research table below.
- 4 vendor recommendations captured from named experts.
- Evidence level in this entry is marked as research.
What is SS-31?
Research compound aggregated from creator and literature mentions. No direct disease-treatment claims are made on this page.
Experts on background and overview · 14 cited mentions
"SS-31 has no immediate benefit on your performance. SS-31 is a protecting compound for your mitochondria, protecting them from oxidative stress, whether it's internally generated or produced outside. SS-31 binds to the cardiolipin molecules within the mitochondrial membrane."
"What one milligram of SS31 still provides protective benefits on cycle or is it worth running more even if the budget is tight? Based on the scientific evidence that I reviewed, the effective dose is 40 milligrams, but not in all contexts."
"SS-31, based on my research, could be very preventative for a lot of the issues that come along with steroids. So, to protect your kidneys from steroids, from boldenone or trenbolone, I think SS-31 at 2 mg to 5 mg daily can be protective."
Show 11 more cited mentions on background and overview →
"the SS-31 deep dive isn't done yet, but it's a wonderful compound at 2 mg to 40 mg daily. I can tell you that. Protect yourself from oxidative stress, especially the mitochondria."
"Add in like 2 mg to 5 mg SS-31 to really help with the cardiolipin in the protective membrane of your mitochondria. And that would enhance the methylene blue, ASU, MOTS-c"
"So if phase one is restoring regenerate, we're using SS-31, tesamorelin, um high dose methylene blue."
"he has this theory that he's been utilizing SS-31. You know how it cleans up oxidative stress, particularly with the mitochondria. If you take it right before a training session, he says that it lowers the time required in between sets."
"I also uh take SS-31 which actually prevents the smoke damage from smoking uh whether that's in the mouth or the lungs. SS-31 is like a condom against smoking."
"SS31 has been studied in humans with several clinical trials. I'm not really far into the research regarding the humans yet to draw an accurate conclusion."
"super complicated these protocols because you're taking a whole lot of different compounds that have no human scientific evidence besides SS-31."
"Did they use SLU SS-31? We've got all these - we're in a different age now of what we can do from a mitochondria perspective."
"you could do the MOTS-c, SLU, methylene blue, and SS-31 stack to keep everything healthy and functional."
"Copy someone's growth hormone and uh maybe some SS-31 to kind of offset the side effects."
"When I was on 5 mg a day, dude, it's like I felt like I could just go... I felt more inclined to do another set, more volume, 45-second rest periods, and just really work a crazy pump."
How does SS-31 work?
Experts on mechanism · 3 cited mentions
"it might be better just to use SS-31 first, which is helping with the mitochondrial membrane and prevents oxidative stress to the mitochondria and from the mitochondria."
"MOTS-c, SS-31, metabolic resilience, mitochondrial protection, and like ATP output efficiency."
"MOTS-c revs it up and SS-31 is going to repair it."
What is SS-31 researched for?
Stabilizes the inner mitochondrial membrane, prevents oxidative stress from leaky mitochondria, and may protect kidneys against steroid-induced damage.
Experts on uses and effects · 2 cited mentions
"boldenone has been shown to cause [oxidative stress in kidneys] in human and animal models. I think SS-31 could protect against that."
"Mitochondrial support such as SS31, MOTS-c."
SS-31 Dosing Protocols
The entries below are transcript-derived dosing mentions. They are preserved for research context and are not medical advice.
| Speaker | Source | Timestamp | Protocol | Evidence |
|---|---|---|---|---|
| Vigorous Steve | Trenbolone’s Minimum Dose, Generic GH Gone, SS-31 Effective Dose,... | 00:07:42 | Steve reported (source iQ9JgQV-VRo) using SS-31 at approximately 1-2 mg/day as a maintenance dose, 5-10 mg/day as a healing dose, and up to 40 mg/day for full medical-condition contexts such as Barth syndrome or dysfunctional mitochondria. Anecdotal; not medical advice. | anecdotal |
| Vigorous Steve | Oral Vs Injectable SLU-PP-332, Ideal GH To Test Ratio, High... | 00:57:45 | Vigorous Steve referenced scientific literature describing 40 mg/day SS-31 in research contexts, and discussed 2-5 mg daily as a preventative range cited by users concerned about steroid-induced kidney damage. Research compound - not for human consumption. | anecdotal |
| Hunter Williams | The MOTS-c Masterclass | Complete Researcher’s Guide (2026) | 00:28:37 | Hunter Williams reported using the following protocol for significant mitochondrial dysfunction concerns: SS-31 alone weeks 1 to 4 at approximately 1, 2, or 5 mg/day, then adding MOTS-c weeks 5 to 12 while continuing SS-31 for at least 4 to 8 weeks. | anecdotal |
| Vigorous Steve | Low-Dose MENT Year-Round, Melt Love Handle Fat, Injectable YK-11,... | 00:23:11 | Vigorous Steve reported using 2 mg to 10 mg of SS-31 for kidney support, and up to 40 mg in cases where kidney damage was already present. Research compound - not for human consumption; educational reporting only. | anecdotal |
| Vigorous Steve | Staying Dry On A Cut, Injectable Oral AAS, Sleep: GH Secretagogues... | 00:37:57 | Steve reported using 2 to 5 mg as an add-on to a mitochondrial stack (methylene blue + ASU + MOTS-c + carnitine) to support cardiolipin in the mitochondrial membrane (anecdotal). | anecdotal |
| Nick | I figured out how to make RETA work 10X better | 00:10:27 | Nick reported starting with 3 to 5 milligrams subq once a day, first thing in the morning, running for the full length of the retatrutide cycle. | anecdotal |
| Vigorous Steve / Steve | Prevent Insulin Resistance On High-Dose GH, Mirabegron Vs. Clen Vs.... | 01:28:55 | Vigorous Steve reported: 2 mg to 5 mg per day alongside injectable SLU/ATX and antioxidants to support cardiolipin and mitochondrial function. | anecdotal |
| Victor | Ranking 12 of the Most Popular FAT LOSS Peptides in 2026 (Best to Worst) | 00:14:23 | Victor reported typical doses of 5 mg to 10 mg subq daily. Some protocols run higher then taper to a maintenance dose over time. | anecdotal |
| Vigorous Steve | Debunking Growth Hormone Myths, Insulin Resistance, Fat Loss,... | 01:15:02 | Anecdotal report: Steve used 40 mg/day continuous dosing for Barth syndrome (an FDA-approved indication for elamipretide/SS-31) | anecdotal |
| Vigorous Steve | Ozempic Issues, Injectable Anadrol, Shrink Gyno, Hypo On Tren, PIP... | 00:46:09 | Steve reported: maintenance 1-2 mg/day; recovery from severe oxidative stress (cigar smoke, CT contrast) 10-40 mg/day | anecdotal |
| Vigorous Steve | GH Secretagogues Vs Real GH, Managing Estradiol On Cycle,... | 01:03:43 | Steve reported using 1mg SS-31 per day stacked with 1mg MOTS-c daily | anecdotal |
| Vigorous Steve | Injectable SLU, AI Dosing Protocol, Glutathione & NAD+, GH & Insulin... | 00:52:54 | Steve reported taking 2 mg/day with MOTS-c before morning cardio | anecdotal |
| The Hunter Williams Podcast | Saturday Morning Coffee Talk 6/20/26 | 01:19:01 | Speaker 1 reported SS-31 first-time dosing protocols of 1 to 2 mg per day for at least 8 to 12 weeks for generally healthy individuals, and 5 to 10 mg per day for those with chronic conditions. | anecdotal |
| Trensparent with Nyle Nayga | Andrew Berry: New Age PED, Insulin, & Peptide Approach to Growth | 00:15:02 | Post-show Phase 1 protocol: SS-31 for 4 weeks during the 'restore and regenerate' phase | anecdotal |
| The Hunter Williams Podcast | The Tesamorelin Masterclass | Complete User's Guide (2026) | 00:31:24 | According to user reports (source: V_Yd07NqXYM), a sequencing suggestion is to use SS-31 during weeks 9-16 before tesamorelin to support mitochondrial function. | anecdotal |
Where to Buy SS-31 in 2026
APR Health Solutions
Code: NYLE (per Nyle's podcast affiliate)Visit vendor → View profile →Recommended by Nyle at 00:34:26.
APR Health Solutions
Code: NYLE (per Nyle's podcast affiliate)Visit vendor → View profile →Recommended by Niles at 00:35:12.
APR Health Solutions
Code: NYLE (per Nyle's podcast affiliate)Visit vendor → View profile →Recommended by Promo voice at 00:24:58.
Optimize HRT
Code: NYLEVisit vendor → View profile →Recommended by Host at 01:53:51.
Side Effects and Safety
Anecdotal reports and study-level observations vary by route, dose, and individual. This page does not provide medical advice. Consult a qualified clinician before any research use.
What Experts Say
6 experts across our source library discuss SS-31. Each entry is that expert’s most context-rich mention: click to watch it at the exact timestamp in the original video. Quotes are also emitted as Schema.org Quotation JSON-LD for AI assistants.
-
“SS-31 has no immediate benefit on your performance. SS-31 is a protecting compound for your mitochondria, protecting them from oxidative stress, whether it's internally generated or produced...”
-
“So if phase one is restoring regenerate, we're using SS-31, tesamorelin, um high dose methylene blue.”
-
“he has this theory that he's been utilizing SS-31. You know how it cleans up oxidative stress, particularly with the mitochondria. If you take it right before a training session, he says that it...”
-
“Did they use SLU SS-31? We've got all these - we're in a different age now of what we can do from a mitochondria perspective.”
-
“MOTS-c, SS-31, metabolic resilience, mitochondrial protection, and like ATP output efficiency.”
-
“MOTS-c revs it up and SS-31 is going to repair it.”
See 12 more expert mentions →
-
“What one milligram of SS31 still provides protective benefits on cycle or is it worth running more even if the budget is tight? Based on the scientific evidence that I reviewed, the effective dose...”
-
“SS-31, based on my research, could be very preventative for a lot of the issues that come along with steroids. So, to protect your kidneys from steroids, from boldenone or trenbolone, I think...”
-
“the SS-31 deep dive isn't done yet, but it's a wonderful compound at 2 mg to 40 mg daily. I can tell you that. Protect yourself from oxidative stress, especially the mitochondria.”
-
“Add in like 2 mg to 5 mg SS-31 to really help with the cardiolipin in the protective membrane of your mitochondria. And that would enhance the methylene blue, ASU, MOTS-c”
-
“I also uh take SS-31 which actually prevents the smoke damage from smoking uh whether that's in the mouth or the lungs. SS-31 is like a condom against smoking.”
-
“SS31 has been studied in humans with several clinical trials. I'm not really far into the research regarding the humans yet to draw an accurate conclusion.”
-
“super complicated these protocols because you're taking a whole lot of different compounds that have no human scientific evidence besides SS-31.”
-
“you could do the MOTS-c, SLU, methylene blue, and SS-31 stack to keep everything healthy and functional.”
-
“Copy someone's growth hormone and uh maybe some SS-31 to kind of offset the side effects.”
-
“it might be better just to use SS-31 first, which is helping with the mitochondrial membrane and prevents oxidative stress to the mitochondria and from the mitochondria.”
-
“boldenone has been shown to cause [oxidative stress in kidneys] in human and animal models. I think SS-31 could protect against that.”
-
“Mitochondrial support such as SS31, MOTS-c.”
User Reviews
User reviews aggregator coming Q3 2026 (Reddit + YouTube comments + Discord research notes). Until then, see the expert quote section above and PubMed citations below.
Research Efficacy Snapshot
Published efficacy percentages cited in PubMed trials and named-expert reports about SS-31. Each line links to the original source.
- "SS-31 significantly improved mitochondrial function, increasing ATP production by 35% and reducing ROS levels by 40% in aged BM-MSCs." · Duan S et al, 2025 PubMed
- "Additionally, SS-31 reduced NOS2 expression by 50%, highlighting its therapeutic potential in age-related bone loss." · Duan S et al, 2025 PubMed
- "and the last one is 50% off and that is for BPC57, TB500, Milanotan 2, Mati, SS31 and I think it's also valid for the CLO and the Glow stacks" · Vigorous Steve / Steve on "Prevent Insulin Resistance On High-Dose GH, Mirabegron Vs. C" @ 1:26
Research and Studies
8 PubMed-indexed papers reference SS-31. Top 8 shown.
Legal Status
SS-31 is presented here as a research compound. FDA approval status, scheduling, WADA status, and state-specific telehealth rules may apply. Always verify current regulatory status. Last verified: 2026-07-09.
Frequently Asked Questions
Is SS-31 FDA-approved?
SS-31 is presented on this page as a research compound. FDA approval status, scheduling, and state-specific rules may apply and change. Verify current regulatory status before any decision.
What dosing is reported for SS-31?
This page aggregates 15 dosing-protocol mention(s) from named-expert transcripts, each linked to a verbatim source timestamp. See the Dosing Protocols table above. Mentions are anecdotal, not medical advice.
Where can I buy SS-31?
4 vendor recommendation(s) are tracked in our directory, sourced from named-expert mentions. See the Where to Buy section above. Always verify COA and current regulatory status.
How much research has been published on SS-31?
8 PubMed-indexed paper(s) reference SS-31 in our current research feed. See the Research and Studies section above for citations.