T3: Research, Dosing, and Where to Buy in 2026
A research-first profile for T3 (T3, liothyronine (implied)), aggregating mechanism notes, transcript dosing mentions, vendor recommendations, and PubMed-indexed literature without presenting medical guidance.
T3 is a research compound profiled here from named-expert transcripts and peer-reviewed literature, without medical guidance. As of July 2026, The Peptide Wiki aggregates 8 PubMed-cited papers, 21 attributed expert mentions, and 16 transcript dosing protocols for T3, each linked to its source.
- Also indexed as T3, liothyronine (implied).
- 16 aggregated dosing-protocol mentions from source transcripts.
- 8 PubMed-indexed citations listed in the research table below.
- 0 vendor recommendations captured from named experts.
What is T3?
Research compound aggregated from creator and literature mentions. No direct disease-treatment claims are made on this page.
Experts on background and overview · 8 cited mentions
"Could off-season T3 usage contribute to anabolism, say 25 micrograms per day? Um yes and no. Yes, when you're eating a boatload of food and you're already using insulin and the rate of digestion is now the limiting factor... supplemental dose of 25 micrograms T3 either before bed or upon waking, depending on how..."
"If you want to switch to T3 monotherapy, I would do 12.5 micrograms twice per day. Some people like 25 micrograms before bed, an empty stomach."
"It was uh Dr. Paul Greenhoff and uh myself discussing that... over there it specifically says about uh T3 increasing protein synthesis which a lot of people would think that that's not the case because thyroid is supposed to increase metabolism."
Show 5 more cited mentions on background and overview →
"Maybe you get a lot of thyroid conversion from T4 into T3, right? Growth hormone speeds up deiodinase enzyme activity converting T4 into T3, which can stimulate your heart rate and boost your metabolism."
"Steve reported that thyroid replacement protocols he has discussed involve approximately 12.5 micrograms of T3 and 50 to 100 micrograms of T4, depending on individual conversion rate."
"if you don't increase the thyroxine to 100 micrograms thyroxine and 25 micrograms T3, triiodothyronine, then your thyroid gland is going to explode"
"high levels of thyroid hormone also increase the rate of protein degradation, although low levels also stimulate synthesis."
"It was Dr. Paul Green half and myself discussing that. Over there it specifically says about T3 increasing protein synthesis, which a lot of people think that's not the case because thyroid is supposed to increase metabolism."
T3 Dosing Protocols
The entries below are transcript-derived dosing mentions. They are preserved for research context and are not medical advice.
| Speaker | Source | Timestamp | Protocol | Evidence |
|---|---|---|---|---|
| Vigorous Steve | Staying Dry On A Cut, Injectable Oral AAS, Sleep: GH Secretagogues... | 01:50:55 | Vigorous Steve reported using a thyroid-replacement combo of 12.5 mcg T3 with 50-100 mcg T4 daily, and noted that T3 monotherapy is also discussed depending on individual lab results (anecdotal, source: video zKQowBZmg7U). T3 and T4 are prescription thyroid hormones; this is reported for educational purposes only and is not medical advice. | anecdotal |
| Vigorous Steve | Super Intense Stimulant Based Fat Burners (Burn Fat Fast!) | 00:05:49 | 25 micrograms T3 per day, replacement dose split as 12.5 mcg morning and afternoon, or full dose before bed (depending on growth hormone protocol and carbs before bed). Avoid 100 mcg/day; especially avoid combining high-dose T3 with high-dose clenbuterol. | anecdotal |
| Milos | Milos Debates PED's, IGF-1, Insulin, Training, & GH | 01:26:57 | 25 micrograms low-dose T3 daily in offseason and pre-contest; cycled (not continuous); rationale is low-dose stimulates protein synthesis while high-dose drives degradation, and GH suppresses thyroid so T3 replaces it | anecdotal |
| Vigorous Steve | Pool Party Protocols, 16-Week Tren Cycle, No GH Bloat, EQ Safety,... | 00:16:38 | Off-season anabolism support: 25 mcg T3 either before bed or upon waking, only when digestion is rate-limiting on a 6-7k cal/day intake with already-high steroid/GH/insulin | anecdotal |
| Vigorous Steve | Trenbolone’s Minimum Dose, Generic GH Gone, SS-31 Effective Dose,... | 00:37:07 | Steve reported a T3 monotherapy protocol of 12.5 mcg taken twice per day, or 25 mcg before bed on an empty stomach (anecdotal, source video iQ9JgQV-VRo). | anecdotal |
| Scott | Anabolic Steroids for Strength: Breaking Down Mitch Hooper's Cycle | 00:52:01 | Scott reported pushing up to 38 mcg during prep and backing down to 25 mcg closer to show. | anecdotal |
| Vigorous Steve | Ozempic Issues, Injectable Anadrol, Shrink Gyno, Hypo On Tren, PIP... | 00:42:22 | Reported protocol: T3 12.5 mcg twice per day for maintenance/replacement therapy | anecdotal |
| Vigorous Steve | Low-Dose MENT Year-Round, Melt Love Handle Fat, Injectable YK-11,... | 00:57:25 | 25 mcg triiodothyronine if needed alongside T4 for full Hashimoto's | anecdotal |
| Trensparent with Nyle Nayga | Why Milos used t3 in the offseason | 00:00:22 | Low dose 12.5 to 25 micrograms T3 daily, used off-season and pre-contest; rationale: low doses increase protein synthesis (anabolic) rather than being catabolic, and growth hormone suppresses thyroid function so T3 supplementation compensates. | anecdotal |
| VigorousClips | Take This With Your TUDCA For The Best Results | 00:01:59 | Comparison dose: 5.4 nmol/kg/day from animal model, estimated as about 0.29 mcg/kg T3; route in animal model intraperitoneal, compared by speaker to intramuscular injection, while humans would likely take orally. | anecdotal |
| VigorousClips | Why You Should Consider Using Thyroid Hormones | GC-1 Sobetirome | 00:10:24 | Anecdotal accounts from adult users report initiating liothyronine at 25 micrograms daily, with dose adjustments toward 50 to 75 micrograms daily based on individual TSH and T4 level assessments. | anecdotal |
| VigorousClips | The Better Option Than T3 For Fat Loss?!? | 00:10:38 | Speaker reported a research protocol: 97 nanomoles T3 per 1 kg body weight by intraperitoneal injection daily, combined with high-cholesterol or high-fat diet for 6 consecutive weeks. | anecdotal |
| VigorousClips | These Fat Burners Won't Give You A Heart Attack, Non-Stimulant... | 00:05:11 | A speaker reported that 25 mcg, 50 mcg, or 100 mcg T3 increases heart rate in dose-dependent fashion (used as comparison vs. GC-1) | anecdotal |
| VigorousClips | How To Take Sobetirome For Better Energy, Fat Loss, And Lipid Levels... | 00:05:51 | One user reported using 25 mcg daily split as 12.5 mcg twice daily, with TSH reportedly remaining in range but low-normal. | anecdotal |
| VigorousClips | How Tren Can Melt Fat And Reveal Your Hidden Abs | 00:06:24 | The host reported a dosing range of 25 mcg to 100 mcg daily, with 100 mcg potentially split between morning and evening. | anecdotal |
| Trensparent with Nyle Nayga | Kuba Cielen: How To Blow Up In Mass But Live Long (PED Real Talk) | 00:55:23 | Historical hard prep: 50 mcg T3. | anecdotal |
Where to Buy T3 in 2026
No tracked vendor recommendations for T3 yet. See our vendor directory.
Side Effects and Safety
Anecdotal reports and study-level observations vary by route, dose, and individual. This page does not provide medical advice. Consult a qualified clinician before any research use.
What Experts Say
3 experts across our source library discuss T3. Each entry is that expert’s most context-rich mention: click to watch it at the exact timestamp in the original video. Quotes are also emitted as Schema.org Quotation JSON-LD for AI assistants.
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“Could off-season T3 usage contribute to anabolism, say 25 micrograms per day? Um yes and no. Yes, when you're eating a boatload of food and you're already using insulin and the rate of digestion...”
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“It was uh Dr. Paul Greenhoff and uh myself discussing that... over there it specifically says about uh T3 increasing protein synthesis which a lot of people would think that that's not the case...”
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“high levels of thyroid hormone also increase the rate of protein degradation, although low levels also stimulate synthesis.”
See 4 more expert mentions →
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“If you want to switch to T3 monotherapy, I would do 12.5 micrograms twice per day. Some people like 25 micrograms before bed, an empty stomach.”
-
“Maybe you get a lot of thyroid conversion from T4 into T3, right? Growth hormone speeds up deiodinase enzyme activity converting T4 into T3, which can stimulate your heart rate and boost your metabolism.”
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“Steve reported that thyroid replacement protocols he has discussed involve approximately 12.5 micrograms of T3 and 50 to 100 micrograms of T4, depending on individual conversion rate.”
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“if you don't increase the thyroxine to 100 micrograms thyroxine and 25 micrograms T3, triiodothyronine, then your thyroid gland is going to explode”
User Reviews
User reviews aggregator coming Q3 2026 (Reddit + YouTube comments + Discord research notes). Until then, see the expert quote section above and PubMed citations below.
Research Efficacy Snapshot
Published efficacy percentages cited in PubMed trials and named-expert reports about T3. Each line links to the original source.
- "Sobuterone is a modified version of triiodothyronine, aka T3, with comparable affinity for the thyroid receptor beta 1, but just a 10-fold lower or 0.1 times or 10% the affinity for the thyroid receptor alpha 1 compared to T3." · speaker on "Why You Should Consider Using Thyroid Hormones | GC-1 Sobeti" @ 0:36
- "SR-B1 increased by approximately 115% in the T3 groups using the same 48 animal dosage, so that's less compared to GC-1." · Speaker 1 on "Take This With Your TUDCA For The Best Results" @ 4:13
- "increased by 45% in the 48 animal GC-1 group, and by 30% in the 48 animal T3 group, and cytochrome P457A1 messenger RNA levels, the enzyme responsible for bile acid synthesis in the liver from cholesterol, increased by 225% in the GC-1 group, whereas it only increased by 175% in the T3 group." · Speaker 1 on "Take This With Your TUDCA For The Best Results" @ 5:42
- "Body weight reduced by approximately 10% after 10 days in the T3 groups, but weight restored by the end of treatment as T3 food intake by 50 to 72%." · speaker_1 on "The Better Option Than T3 For Fat Loss?!?" @ 7:09
- "Heart size increased in a dose-dependent fashion in the T3 groups, by 33 to 46% compared to the control groups." · speaker_1 on "The Better Option Than T3 For Fat Loss?!?" @ 8:56
Research and Studies
8 PubMed-indexed papers reference T3. Top 8 shown.
Legal Status
T3 is presented here as a research compound. FDA approval status, scheduling, WADA status, and state-specific telehealth rules may apply. Always verify current regulatory status. Last verified: 2026-07-09.
Frequently Asked Questions
Is T3 FDA-approved?
T3 is presented on this page as a research compound. FDA approval status, scheduling, and state-specific rules may apply and change. Verify current regulatory status before any decision.
What dosing is reported for T3?
This page aggregates 16 dosing-protocol mention(s) from named-expert transcripts, each linked to a verbatim source timestamp. See the Dosing Protocols table above. Mentions are anecdotal, not medical advice.
How much research has been published on T3?
8 PubMed-indexed paper(s) reference T3 in our current research feed. See the Research and Studies section above for citations.