Tesofensine: Research, Dosing, and Where to Buy in 2026
A research-first profile for Tesofensine, aggregating mechanism notes, transcript dosing mentions, vendor recommendations, and PubMed-indexed literature without presenting medical guidance.
Tesofensine is a research compound profiled here from named-expert transcripts and peer-reviewed literature, without medical guidance. As of July 2026, The Peptide Wiki aggregates 8 PubMed-cited papers, 7 attributed expert mentions, and 1 transcript dosing protocol for Tesofensine, each linked to its source.
- 1 aggregated dosing-protocol mention from source transcripts.
- 8 PubMed-indexed citations listed in the research table below.
- 0 vendor recommendations captured from named experts.
- Evidence level in this entry is marked as research.
What is Tesofensine?
Research compound aggregated from creator and literature mentions. No direct disease-treatment claims are made on this page.
Experts on background and overview · 3 cited mentions
"the efficacy of tesofensine works if your dose is individualized... it's an SNDRI, so it's similar as other SNDRIs. And downsides is that when you stop it, you get withdrawal symptoms."
"the anidonia might still be there in jeepite. So you would need to address that with elyroine or uh tesopenine or um vitamin B6 B5P supplementation right to bring your dopamine levels up."
"You could switch to Zepbound or tesofensine or or or Adderall or another kind of appetite suppression [during a Retatrutide tolerance break]."
How does Tesofensine work?
Experts on mechanism · 1 cited mention
"it's a selective norepinephrine, dopamine, and serotonin reuptake inhibitor... Man, that felts like... combination of of micro doing LSD and MDMA the first day."
What is Tesofensine researched for?
Triple monoamine reuptake inhibitor (NE/DA/5-HT); intense stimulant-like effects and appetite suppression.
Tesofensine Dosing Protocols
The entries below are transcript-derived dosing mentions. They are preserved for research context and are not medical advice.
| Speaker | Source | Timestamp | Protocol | Evidence |
|---|---|---|---|---|
| The Hunter Williams Podcast | Saturday Morning Coffee Talk 6/20/26 | 01:11:50 | Speaker 1 reported: if capsules are 500 mcg and cannot be reduced, using 500 mcg three times per week due to tesofensine's long half-life, while tapering off retatrutide. | anecdotal |
Where to Buy Tesofensine in 2026
No tracked vendor recommendations for Tesofensine yet. See our vendor directory.
Side Effects and Safety
Anecdotal reports and study-level observations vary by route, dose, and individual. This page does not provide medical advice. Consult a qualified clinician before any research use.
What Experts Say
1 expert across our source library discuss Tesofensine. Each entry is that expert’s most context-rich mention: click to watch it at the exact timestamp in the original video. Quotes are also emitted as Schema.org Quotation JSON-LD for AI assistants.
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“the efficacy of tesofensine works if your dose is individualized... it's an SNDRI, so it's similar as other SNDRIs. And downsides is that when you stop it, you get withdrawal symptoms.”
See 3 more expert mentions →
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“the anidonia might still be there in jeepite. So you would need to address that with elyroine or uh tesopenine or um vitamin B6 B5P supplementation right to bring your dopamine levels up.”
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“You could switch to Zepbound or tesofensine or or or Adderall or another kind of appetite suppression [during a Retatrutide tolerance break].”
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“it's a selective norepinephrine, dopamine, and serotonin reuptake inhibitor... Man, that felts like... combination of of micro doing LSD and MDMA the first day.”
User Reviews
User reviews aggregator coming Q3 2026 (Reddit + YouTube comments + Discord research notes). Until then, see the expert quote section above and PubMed citations below.
Research Efficacy Snapshot
Published efficacy percentages cited in PubMed trials and named-expert reports about Tesofensine. Each line links to the original source.
- "In the placebo group, 14% were obese and 21% were in the TE group." · Astrup A et al, 2008 PubMed
- "In the total cohort, weight change after 14 weeks was +0.5, -0.5, -0.9, -1.8, -2.8% in the placebo, 0.125, 0.25, 0.5 and 1.0 mg in the TE groups, respectively (P = 0.015 for dose effect)." · Astrup A et al, 2008 PubMed
- "In the obese subgroup, weight changes were -0.2, -1.7, -1.6, -1.5, -3.7%, and 2.1, 8.2, 14.1, 20.9, 32.1% of the obese patients achieved > or = 5% weight loss (P < 0.001 for 0.25, 0.5, and 1.0 mg vs." · Astrup A et al, 2008 PubMed
- "TE produced a placebo-subtracted weight loss of approximately 4% for >14 weeks without any diet and lifestyle therapy, which is similar to that of sibutramine, but with no effect on blood pressure." · Astrup A et al, 2008 PubMed
Research and Studies
8 PubMed-indexed papers reference Tesofensine. Top 8 shown.
Legal Status
Tesofensine is presented here as a research compound. FDA approval status, scheduling, WADA status, and state-specific telehealth rules may apply. Always verify current regulatory status. Last verified: 2026-07-09.
Frequently Asked Questions
Is Tesofensine FDA-approved?
Tesofensine is presented on this page as a research compound. FDA approval status, scheduling, and state-specific rules may apply and change. Verify current regulatory status before any decision.
What dosing is reported for Tesofensine?
This page aggregates 1 dosing-protocol mention(s) from named-expert transcripts, each linked to a verbatim source timestamp. See the Dosing Protocols table above. Mentions are anecdotal, not medical advice.
How much research has been published on Tesofensine?
8 PubMed-indexed paper(s) reference Tesofensine in our current research feed. See the Research and Studies section above for citations.